The effects of Ta and Nb element content on the organization and properties of ERNiCrFe-13 nickel-based alloy wire（1# wire high Ta and low Nb, 2# wire high Nb and low Ta） deposited metal were studied comparatively by optical microscope（OM）,scanning electron microscope（SEM）,energy dispersive spectrometer（EDS）,tensile test and impact test. The results show that the microstructure of deposited metal of 1# welding wire and 2# welding wire is columnar dendrite, and there is segregation zone, and there are precipitates on the segregation zone. The precipitates of 1#welding wire are mainly carbide and Laves phase, with an area of about 0.5～2 μm,2,;in addition to carbide and Laves phase, the precipitated phase of 2# welding wire also exists σ Phase harmony γ/Laves phase eutectic structure, the area of precipitated phase is about 3～10 μm,2,;the mechanical properties of the deposited metal of 1#welding wire are much higher than the required value, meeting the safety application conditions in nuclear power engineering. The impact properties of the deposited metal of 2# welding wire are poor. On the whole, the mechanical properties of the deposited metal of 1# welding wire are better than that of 2# welding wire. During the development of nickel-based alloy wire, the formation of Laves and σ phases in the molten metal should be minimized.