The anti debris plate of AISI 660 is an important core functional part of HPR1000 nuclear fuel assembly, which is used to filter the debris in the fluid to prevent the abrasion and damage of the nuclear fuel cladding. There are nearly 2 000 square or circular holes on the anti debris plate with the overall dimension of about 220 mm square sheet. The size accuracy and position of the holes are very high, so it is difficult to process. In this project, the laser cutting process and its key characteristics are studied from the aspects of laser cutting pretreatment, cutting process, key process parameters, and post-processing. Finally, the laser cutting anti debris plate samples and supporting manufacturing process are successfully trial produced. This research provides a new research idea and direction for solving the technical problems in domestic nuclear fuel manufacturing.