The axle-box body of high-speed train is mainly made of nodular cast iron with heavy overall quality.According to the lightweight requirement of 400 km/h high-speed train,the axle-box structure is redesigned according to the forming characteristics of aluminum alloy materials. The three-dimensional model and finite element model of alu-minum alloy axle-box is established by CERO and ANSYS,respectively. Based on the EN 13749-2005 standard,the stress state and fatigue strength of aluminum alloy axle-box under the super load and operation conditions are analyzed by ANSYS Workbench. Through static strength and fatigue strength analysis,the safety and reliability of aluminum alloy axle-box structure are verified.