The Box-Behnken response surface analysis method was used to optimize the surface morphology of the laser tailor-welding.The four factors,welding voltage,pulse frequency,pulse width,speed of welding,were selected for experimental design. The secondary response surface model was obtained. The response surface analysis show that the welding pressure and pulse frequency have a great influence on the morphology of the weld,followed by the welding speed and pulse width. Through optimization,it is found that when the welding voltage,pulse frequency,pulse width and welding speed are 265.42 V,19.65 Hz,10.22 ms,and 321.26 mm/min,respectively,the weld morphology is best. Moreover,the F value is 5.51 obtained by the model variance,indicating that the quadratic equation is significant. The model fitted well in the entire regression region,which could be used to analyze and predict the process of the weld morphology. Through the experimental comparison and analysis,it is found that the welding morphology,microstructure and hardness values are better under the optimal process parameters.